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KMID : 0385520140270050248
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Analytical Science & Technology
2014 Volume.27 No. 5 p.248 ~ p.253
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Effects of low-level exposure to manganese and lead on immune function
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Kim Ki-Woong
Won Yong-Lim
Park Sang-Hwoi
Lee Sung-Kwang
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Abstract
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This study aimed to evaluate the effects of exposure to manganese (Mn) and lead (Pb) on immune system. The subjects were 42 male workers, among whom 13 office workers (Group I) had never been occupationally exposed to heavy metals, 21 were worked in manufacturing factories (Group II) and 8 were welders (Group III). The mean blood Mn and Pb level by groups were significantly different. The numbers of CD19+ and total lymphocytes in Group I were significantly higher than those in other groups, but no significant differences were found in other T lymphocytes subpopulation. Mn and Pb concentrations showed negative correlation with T lymphocytes subpopulation, but Mn concentrations were statistical significances with T lymphocytes subpoplation except CD4+CD45RO+ and natural killer cell. Pb concentration was only statistical significance with total lymphocytes. Our results suggest that occupationally exposed to Mn and Pb can affect
the cellular immune response.
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KEYWORD
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immune system, T lymphocytes subpopulation, immunoglobulins, manganese, lead,
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